Creative Biolabs is a leading service provider that focuses on the treatment of autoimmune diseases for years. By combining cutting edge technologies with proprietary innovations, scientists at Creative Biolabs provide a full range of novel drug development services for diverse body systems, such as thyroid and parathyroid gland. Our technology provides a broadly applicable combination treatment for a wide range of autoimmune disease types. Nowadays, we are committed to bringing deep domain expertise to assist our clients in achieving their strategic and operational objectives.
Thyroid and parathyroid glands are endocrine glands that play an important role in regulating the production and secretion of hormones. These hormones can affect most human cells and tissues and have been treated as messengers. In particular, thyroid hormones, such as thyroxine (T4) and triiodothyronine (T3), are essential for mediating the metabolic rate of the human body and the levels of mineral content in human blood. Moreover, many studies have demonstrated that parathyroid hormone can be used to control the number of minerals, including calcium, phosphorus, and magnesium. Besides, recent reports have indicated that the improper functioning of the thyroid and parathyroid glands are associated with the occurrence and progression of various autoimmune diseases, such as hypoparathyroidism and Graves' disease. For the treatment, antithyroid drugs, radioactive Iodine (RAI), and surgery have become the standard methods for treating these diseases. The data have shown that these methods are effective in patients, but can cause some side effects.
Fig.1 Human parathyroid glands are embedded in the anterior (frontal) surface of the thyroid gland. (Matheys, et al., 2015)
At Creative Biolabs, we focus on disorders and conditions of both the thyroid and parathyroid. Our scientists specialized in new drug development will provide a wide range of thyroid and parathyroid gland disease-based services to meet any special requirement of your projects, spanning from antibody discovery to cell-based therapy.
The thyroid is the main gland that regulates the metabolism in the human body. In general, it is a butterfly-shaped gland located in the anterior and lower part of the neck. Some of the most common thyroid diseases include autoimmune hyperthyroidism, Hashimoto's disease, as well as Graves' disease. Among them, autoimmune hyperthyroidism is usually caused by an excess of hormones produced by the thyroid gland. Hashimoto’s disease is a condition that can lead to inflammation of the thyroid gland and impaired thyroid hormone function. Also, Graves’ disease is an autoimmune disorder that often results in an enlarged thyroid. Nowadays, Creative Biolabs has developed criteria protocols to design, generate, and evaluate the safety and efficacy of novel drugs or therapies, such as monoclonal antibody drugs, bispecific antibody drugs, cell-based therapy, for improving patient outcomes in clinical use.
The parathyroid gland can produce a specific parathyroid hormone (PTH), which can help mediate the balance of calcium and phosphorous in the blood. Currently, we are capable of providing anti-parathyroid antibody development workflows to reduce overall cost and shorten development time. For instance, antigens of parathyroid cells can be collected from patient sera. Our antibodies do not target parathyroid hormones, but cytoplasmic antigens of parathyroid cells.
Through our comprehensive early discovery, nonclinical, and commercialization services, Creative Biolabs is committed to developing the most promising drugs for treating thyroid and parathyroid gland diseases. With in-depth expertise in antibody design and safety assessment, we can provide a series of drug discovery services basing on a full range of state-of-art technologies. We will help our worldwide customers bring new antibodies or cell-based therapies into the market for a wide range of autoimmune disease treatments.
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Creative Biolabs is a world-leading CRO that is skilled in developing novel therapies,
especially in antibody and cell therapy for autoimmune diseases.
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