Celiac Disease (CeD) Drug Development

Many advances have been achieved in the understanding of the pathogenic interactions among many factors in celiac disease (CeD), with a particular emphasis on the intestinal barrier and gut microbiota. Creative Biolabs has more than 10 years of experience in drug development, we provide comprehensive services of antibody development and cell-based therapy for CeD to customers around the world.

Introduction to Celiac Disease (CeD)

CeD is one of the most common food-related, lifelong disorders in the world. Once CeD is considered a rare small bowel disease of childhood, now it is recognized as a relatively common, systemic disease that may manifest at any age. This disease is triggered by the ingestion of gluten and presents some symptoms such as vomiting, constipation, malnutrition, diarrhea, osteoporosis, or migraines, and chronic fatigue.

Treatment of CeD

A potential therapeutic method for CeD is the epithelial mitogens that can stimulate mucosa growth. In a study, R-spondin-1 has been shown to stimulate crypt cell growth, accelerate mucosal regeneration, and restore intestinal architecture in experimental colitis in mice.

Schematic representation of the crypt/villus axis. Fig.1 Schematic representation of the crypt/villus axis. (Piscaglia, 2014)

The other potential therapeutic method for CeD is the transplantation of multipotent extraintestinal stem cells (SCs). A doctor treated one celiac patient with allogeneic hematopoietic stem cells (HSCs) transplant preceded. Similarly, another report suggested that in one patient with severe aplastic anaemia and CeD, allotransplant of SCs resulted in the cure of CeD even after the return to a free diet.

Our Drug Development Services

If you want to get high-quality antibodies, you should firstly design high-quality antigens. With more than millions of monoclonal antibodies successfully developed, Creative Biolabs has a large number of antigen design solutions, which can meet any needs in the early stage of drug development. Next, professional scientists with the highest expertise on the market will give you a strategy that helps you to generate high-quality antibodies. Finally, our team will carry out a series of tests to help you develop antibodies with high affinity and specificity. Creative Biolabs provides you with the best services, including but not limited to:

  • Monoclonal Antibody Development for CeD
  • Bispecific Antibody Development for CeD
  • Cell-based Therapy for CeD

Creative Biolabs has industry-leading experience in the development of therapeutic antibodies and cell therapy. We can provide first-class services to our customers all over the world. If you still have doubts about CeD drug development, please ask an expert for a specific consultation on your project as soon as possible.

Reference

  1. Piscaglia, A. C. Intestinal stem cells and celiac disease. world journal stem cells. 2014, 6(2): 213-229.

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