The systemic autoimmune diseases can cause a variety of gastrointestinal (GI) manifestations. Because in an autoimmune reaction, the immune system attacks by mistake and harms the body's tissues. The GI system includes the mouth, throat, esophagus, stomach, small intestine, large intestine, rectum, and anus. The primary functions of the GI tract are digestion, absorption, excretion, and protection. The stomach and small intestine are principally responsible for digestion and absorption, a process incorporating both physical and chemical mechanisms. The large intestine is primarily concerned with desiccation and compaction of waste, with storage in the sigmoid colon and rectum before elimination.
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