Rheumatoid Arthritis (RA) Drug Development

With ample experience in the research of autoimmune diseases, Creative Biolabs provides antibody development and cell-based therapy development services for autoimmune diseases such as rheumatoid arthritis (RA) to customers around the world.

Introduction to Rheumatoid Arthritis (RA)

RA is a complex inflammatory autoimmune disease. It is characterized by chronic inflammation in the synovial membrane of affected joints. Firstly, it affects small joints, then larger joints, eventually the skin, eyes, heart, kidneys, and lungs. All this damage to the joints causes deformities and bone erosion. Patients are very painful.

Treatment of RA

  • B cells can suppress autoimmunity in different animal models either through the production of interleukin 10 (IL-10) or transforming growth factor-β (TGFβ) as well as by cytokine independent functions. A study has demonstrated that a transitional-marginal zone precursor B cell subset is protective against murine inflammatory arthritis via the production of IL-10. In another study, B cells in the joints of patients with RA may directly participate in receptor activator of nuclear factor κB ligand (RANKL) synthesis and indirectly modulate the RANKL/osteoprotegerin (OPG) system through the production of proinflammatory cytokines, such as tumor necrosis factor (TNF) and interleukin 17A (IL-17A).

Bone erosions are augmented in the IL-10KO joints following antigen-induced arthritis (AIA) Fig.1 Bone erosions are augmented in the IL-10KO joints following antigen-induced arthritis (AIA). (Greenhill, 2014)

  • Non-steroidal anti-inflammatory drugs (NSAIDs) work by inhibiting cyclo-oxygenase to prevent the synthesis of prostaglandins, prostacyclin, and thromboxanes. Aspirin is an effective anti-inflammatory for RA when used at high doses, due to the inhibition of prostaglandins. It is one of the oldest NSAIDs used for joint pain. Side effects of aspirin at high doses include tinnitus, hearing loss, and gastric intolerance.
  • Corticosteroids are a more potent anti-inflammatory medication than NSAIDs. They work by preventing the release of phospholipids and decreasing the actions of eosinophils, thereby decreasing inflammation. Their side effects include bone-thinning, weight gain, diabetes, and immunosuppression.

Our Drug Development Services

Cell therapy represents the most recent phase of the biotechnology revolution in medicine. As with many remedies, cell therapies are based on ground-breaking scientific discoveries and technological advancements. We focus on the research of cell therapy and antibody development. With many years of antibody development experience, Creative Biolabs has the broadest scientific research platform, so we can provide you with the best services, including but not limited to:

  • Monoclonal Antibody Development for RA
  • Bispecific Antibody Development for RA
  • Cell-based Therapy for RA

Creative Biolabs is a dedicated provider that strives to offer the highest quality RA drug development services for our customers worldwide. We would be pleased to provide support for any of your questions. Please ask an expert for a specific consultation on your project.

Reference

  1. Greenhill, C.; et al. Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Research & Therapy. 2014, 16(4): 419.

For Research Use Only | Not For Clinical Use



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Autoimmune Diseases,Drug Development for
Autoimmune Diseases

Creative Biolabs is a world-leading CRO that is skilled in developing novel therapies,
especially in antibody and cell therapy for autoimmune diseases.

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