As a well-recognized expert in drug development for autoimmune diseases, Creative Biolabs offers worldwide clients high-quality and comprehensive solutions to advance the development of novel therapies for autoimmune diseases.
A healthy immune system protects you from outside threats like viruses, bacteria, and infection. However, autoimmune diseases occur when your immune system is unable to distinguish between your own cells and foreign cells and mistakenly attacks normal cells. There are more than 100 types of autoimmune diseases, some of which are organ-specific, such as primary biliary cirrhosis (PBC), and others are associated with multiple organ immune dysfunctions, such as systemic lupus erythematosus (SLE). Common symptoms include fatigue, joint pain and swelling, skin rash, recurring fever, and swollen glands. The National Institutes of Health assesses more than 23.5 million Americans suffer from an autoimmune disease.
Conventional treatments for autoimmune diseases include immunosuppressive agents and anti-inflammatory drugs. These drugs can nonspecifically reduce the symptoms of autoimmune disease, however, they have potentially serious side effects such as reducing the normal immune response and increasing the risk of infections. Currently, scientists have proposed and developed many new and promising treatments for autoimmune diseases, including biologics (e.g. monoclonal antibodies, fusion proteins, molecular mimics), cell therapy, gene therapy, and antigen-specific immunotherapy. These therapies are designed to suppress the deleterious effects of self-reactive immune-cell function while maintaining the ability of the immune system to clear non-self antigens. Biologics targeting inflammatory and/or effector pathways such as TNF and IL-23 are developed to reduce autoimmunity by blocking the cytokine pathways, depletion of T cells or B cells, and increasing immunomodulation function. Cell therapies, typically including T regulatory (Treg) cells, dendritic cells (DC), and mesenchymal stem cells (MSC), exhibit a great potential for the treatment of autoimmune diseases by inducing immune tolerance and suppressing autoimmune responses. Besides, repeated exposure to autoantigens has been shown to increase the number of antigen-specific regulatory T cells, thereby inhibiting the ongoing autoimmune response. These autoantigens can also be modified to induce self-tolerance more effectively.
Creative Biolabs is a world-leading CRO company. We have organized a staff of excellent scientists who are skilled in developing novel therapies, especially antibody and cell therapy, for autoimmune diseases. We are committed to becoming your reliable partner in the field of drug development for autoimmune diseases. For antibody development, we have established several powerful technologies including phage display, hybridoma, and B cell sorting. We are confident in offering the best and most comprehensive services for developing novel therapeutic antibodies for autoimmune diseases in a time- and cost-effective manner. For cell therapy, we support one-stop cell therapy development services, including cell culture, cell engineering, and preclinical therapeutic testing.
If you are interested in our services, please feel free to contact us for more details.
For Research Use Only | Not For Clinical Use