Creative Biolabs is a leading servicer with many years of experience in the drug development field. Our researchers have earned an excellent reputation from our clients for superior customer services. Based on vast experience and solid technical strength, we will maximize your success in discovering high-value drugs for your autoimmune oophoritis research.
Autoimmune oophoritis is a rare disorder causing ovarian failure by autoimmune inflammation of ovaries resulting in their destruction, atrophy, and fibrosis. It is characterized by intense lymphocytic infiltration of developing follicles and the specific targeting of ovarian autoantibodies to the theca cells to preserve the granulosa cells. The affected ovaries may be cystically enlarged, and there is a subsequent loss of fertility and ovarian hormonal function. Autoimmune oophoritis often occurs in autoimmune polyendocrine syndromes and is commonly associated with Addison's disease and Hashimoto's thyroiditis.
Standard treatment outcome for infertility is less effective in the presence of autoimmune oophoritis. For young patients with autoimmune oophoritis who desire pregnancy, high doses of corticosteroids might help achieve pregnancy.
Previous studies illustrated the possible effects of immunomodulating therapy on the resumption of ovarian function and fertility in a selected group of patients with autoimmune oophoritis. Although there are no effective therapeutic antibodies for the treatment of autoimmune oophoritis, immunosuppressive agents, such as corticosteroids or tacrolimus, may positively affect restoring ovarian function to be useful in the treatment of autoimmune oophoritis. Therefore, the development of a new antibody-based immunosuppressive treatment possibly helps restore fertility. Moreover, autoimmune oophoritis involves a complex interplay of humoral and cellular mechanisms, which provokes premature ovarian failure; thus, cell-based therapy may also have potential value for the treatment of autoimmune oophoritis.
As a leading CRO for drug development, Creative Biolabs offers custom autoimmune oophoritis drug development services for our global customers. By partnering with Creative Biolabs, you will gain access to drug development supports that increase your research potential to be successful. We provide a series of integrated and advanced platforms for you to choose the most suitable drug development strategies, including but not limited to:
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