Drug Development for Autoimmune Diseases

Although autoimmune diseases are rare, they affect 14.7 to 23.5 million people in the world. Currently, cures are not yet available for most autoimmune diseases and patients face a lifetime of illness and treatment. Hence, it is necessary to develop effective drugs for the treatment of autoimmune disease. Creative Biolabs is focused on developing novel therapies for autoimmune diseases by harnessing our extensive expertise and well-established drug development technologies. Our featured services include monoclonal antibody development, bispecific antibody development, and cell-based therapy development. We are committed to becoming your best partner to develop novel and effective drugs for autoimmune diseases.

Treatment for Autoimmune Diseases

Autoimmune diseases develop when underlying defects in the immune system lead the body to attack its organs, tissues, and cells. Common autoimmune diseases include rheumatoid arthritis (RA), inflammatory bowel disease (IBD), type 1 diabetes, multiple sclerosis (MS), and systemic lupus erythematosus (SLE). More than 23.5 million people in the U.S. suffer from autoimmune diseases. Now there is no cure for autoimmune diseases. Common treatments including immunosuppressive agents and anti-inflammatory drugs aim to relieve symptoms like pain, swelling, fatigue, and skin rashes. Moreover, these treatments are expensive and come with side effects. Therefore, it is necessary to develop effective, safe, and low-cost drugs for the treatment of autoimmune diseases. At present, many novel therapeutic strategies are being investigated including monoclonal antibodies, fusion proteins, molecular mimics, cell therapy, gene therapy, and antigen-specific immunotherapy. These therapies aim to suppress the harmful effects of hyperactivity immune responses while maintaining the immune system's ability to fight non-self antigens.

Monoclonal Antibody Development for Autoimmune Diseases

Monoclonal Antibody Development for Autoimmune Diseases (Creative Biolabs)

Monoclonal antibodies (mAbs) have been successfully used for the treatment of a wide variety of autoimmune diseases, most particularly in RA and MS. With the understanding of the mechanism of autoimmunity, it is now possible to develop mAbs targeting every single step of the immune process from the activation of T lymphocytes in lymph nodes to T cell differentiation and cytokine production. Activation antigens (interleukin-2 receptor), pan-T cell antigens (CD2 and CD3), and T cell subset-specific antigens (CD4) are the most common targets of mAbs against autoimmune diseases.

Bispecific Antibody Development for Autoimmune Diseases

Bispecific Antibody Development for Autoimmune Diseases (Creative Biolabs)

A bispecific antibody combines two distinct binding specificities within a single biologic to allow the simultaneous targeting of multiple disease-causing cytokines or pathways. Bispecific antibodies offer attractive new opportunities for the design of novel therapeutics for autoimmune diseases which are regulated by diverse cytokines.

Cell-based Therapy for Autoimmune Diseases

Cell-based Therapy for Autoimmune Diseases (Creative Biolabs)

Several T-cell subsets have been identified to have the ability to inhibit immune responses to a variety of self-antigens and nonself-antigens, such as natural regulatory T (Treg) cells, natural killer T cells, and myelomonocytes. Naturally occurring FoxP3+CD4+ Treg cells are indispensable for the maintenance of immunological self-tolerance and homeostasis. They are expected to be used for treating autoimmune and other immunological disorders. Natural killer T cells activated in vivo with α-galactosylceramide have been successfully tested in various animal models of autoimmune disease.

Our Capability

Creative Biolabs has assembled a team of world-class leaders who are skilled in exploring and identifying novel therapeutics for autoimmune disease. Supported by the experienced leadership team and powerful technical platforms, we provide a full range of therapeutic antibody development and cell therapy development services for global clients. If you are studying novel drugs for treating autoimmune diseases, please don't hesitate to contact us to discuss your project. We are thrilled to become your reliable partner to develop novel therapies for autoimmune diseases.

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Autoimmune Diseases,Drug Development for
Autoimmune Diseases

Creative Biolabs is a world-leading CRO that is skilled in developing novel therapies,
especially in antibody and cell therapy for autoimmune diseases.

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