Acquired Neuromyotonia Drug Development

Introduction to Acquired Neuromyotonia (NMT)

Acquired neuromyotonia (NMT) is an immune disorder that is characterized by cramps and fasciculations (twitching or flickering of muscles) due to peripheral nerve hyperexcitability. This situation can affect all limb and trunk muscles. The autonomic nervous system can also be affected and this may present as gastrointestinal symptoms such as bloating, burping and altered bowel habits, or excessive sweating. With more than 10 years of scientific research experience, Creative Biolabs pays attention to solving research problems for customers. For autoimmune diseases, such as acquired neuromyotonia, our scientists apply their expertise to provide antibody development and cell therapy services.

Tab.1 Clinical and laboratory features of the patients with NMT. (Hayat, 2000)

Acquired Neuromyotonia Drug Development

Current Treatments for NMT

  • Intravenous Immunoglobulin (IVIg): IVIg can be made from pooled human serum or laboratory. It includes many different proteins which can cause antibodies and relieve the symptoms. Patients receive intravenous infusions of the IVIg at 4 weekly intervals.
  • Plasma Exchange: This is a more invasive and costly treatment. Plasma exchange is reserved as a second-line treatment. This involves removing the patient’s blood, washing it, and returning the blood cells with added fluid to the patient.
  • Symptomatic treatment: Symptomatic treatment for the cramps is given in the form of anti-epileptic drugs such as carbamazepine.

Acquired Neuromyotonia Drug Development (Creative Biolabs)

Services at Creative Biolabs

Early target selection and antibody acquisition are very important for the development of drugs. We have a perfect technical platform for antigen design, antibody preparation, screening, and identification. We have rich practical experience and have completed millions of projects. Cell-based therapy represents a new paradigm of drug development, which has been proved to be effective for cancer and infectious diseases. For autoimmune diseases, we also provide some services that include but not limited to:

  • Monoclonal Antibody Development for NMT
  • Bispecific Antibody Development for NMT
  • Cell-based Therapy for NMT

As a leader in the field of immunology, we have rich scientific research experience. Creative Biolabs provides T cell and B cell development services. Our mission is to help customers solve scientific research problems. If you are interested in our services, please contact us.

Reference

  1. Hayat, G. R.; et al. Neuromyotonia: autoimmune pathogenesis and response to immune-modulating therapy. Journal of the Neurological ences. 2000, 181(1): 38-43.

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